The top Nattokinase products reviewed.

Nattokinase is known for its ability to dissolve the spike protein, reduce blood clots, improve cardiovascular health, support immune health, and more.

Derived from a traditional Japanese food called natto, Nattokinase is a naturally-occurring enzyme found in soybeans.

Which supplement is the best?

We've done the hard work and researched the best supplements for better health as a public service to health-minded people because we're strong believers in the science being Nattokinase.

This post may contain affiliate links.

Our clear favorite:

Signature Series Spike Support Formula from The Wellness Company.


Signature Series Spike Support Formula

The Wellness Company's bespoke Spike Formula has acclaimed reviews and contains scientifically-researched ingredients, including nattokinase and selenium which multiple research studies indicate may dissolve the spike protein.

With research backed by experts including Dr. Peter McCullough and The Wellness Company's Chief Medical Board, Signature Series Spike Formula is our favorite because of its unique formulation, science-backed research, and transparency.

This formulation also includes additional, well-researched ingredients to support the body's ability to heal and become healthier, including dandelion root, black sativa extract, green tea extract, and Irish sea moss.

Why we love Spike Support Formula

Contains non-GMO Nattokinase

Nattokinase is the key ingredient which is believed to dissolve the spike protein in addition to multiple cooperative ingredients to supplement your health.
Better yet, Spike Support Formula is made in the USA, is non-GMO, vegan, and gluten-free.

Saves you 36% per bottle

Armed with additional ingredients to support the body's healing potential and increase your body's immune system, Spike Support Formula saves you 36% per bottle compared to buying each individual ingredient separately.

Nattokinase is backed by the biggest names, including Dr. Peter McCullogh and Dr. Robert Malone

Some of the biggest leaders in fact-based science have put their names and reputation behind this product, including Dr. Peter McCullough – and TWC also cites scientific studies in their formulation.

Free shipping and more

The Wellness Company offers free shipping – and with a TWC Membership or a subscription plan, customers can also enjoy additional discounts.

Plus, TWC now offers savings when bundling up to ten supplements.

Spike Support Formula is only available directly from The Wellness Company.

$65.99 (or less with a TWC Membership) for a one-month supply

Real Signature Series Spike Support Formula customer reviews

I bought this product specifically because I knew I'd be working in the company of "vaccinated" folks. And I'm familiar with the shedding phenomenon. I'll continue taking this product for the rest of my life. It's given me peace of mind knowing I'm protecting myself not only at my place of employment, but from any other exposure I may come in contact with.

Debbie B.
United States

I was worried about shedding – and after I saw Dr. McCullough talk about the product which contains Nattokinase, I decided to give it a try. A month and a half later, I feel sooo much better. I've recommended the product to family members. Would recommend this to everyone in our post-pandemic world.

There's zero downside in giving it a try.

Meredith P.
United States

Shipping was prompt and it arrived intact.

I started the Spike Support Formula regiment and am hoping to minimize the spike protein damage incurred from forced vaccination.

Thank you for your great info and support of the truth in these times.

Stephan D.

Other runner-ups to consider


Solaray Nattokinase with Serrapeptase contains 3,000 FUs and focused on digestive health with its formulation including serrapeptase. While it's GMO status is unknown to us, Solaray's formulation is a good contender.

3,000 FU (fibrinolytic units)
Digestive support
Includes Serrapeptase
Focused on digestive health
GMO status unknown

Source Naturals

Source Naturals' Nattokinase softgels contain 2,000 FUs in its formulation -- and that's it. Plain and simple. However, its softgels contain gelatin, making this non-vegetarian and non-vegan.

2,000 FU
30 capsules
GMO status unknown

Doctor's Best

Doctor's Best Nattokinase provides basic Nattokinase with 2,000 FUs in a vegan, non-GMO formulation.

2,000 FU
270 capsules

Cardiovascular Research Ltd Nattokinase

Cardiovascular Research's Nattokinase formulation claims to include pyrroloquinoline quinone, or PQQ, which some believe supports cardiovascular circulation and has anti-aging properties. However, no mention of PQQ is on the required Supplement Facts.

1,000 FU
90 capsules
GMO status unknown
PQQ status unknown

Now Foods

Now Foods' Nattokinase is a non-GMO vegan-friendly supplement that is formulated with only nattokinase.

2,000 FU
60 capsules

Get Spike Support Formula directly from The Wellness Company.

$65.99 for a one-month supply (or less with a TWC Membership)